Antithrombin III is not an Indicator of Dialyzer Biocompatibility

The role of dialyzer biocompatibility in acute renal failure.

Antimicrobial antithrombin III peptide 1 Antimicrobial effects of helix D-derived peptides of human antithrombin III*

Antithrombin III (ATIII) is a key antiproteinase involved in blood coagulation. Previous investigations have shown that ATIII is degraded by Staphylococcus aureus V8 protease, leading to release of heparin binding fragments derived from its D helix. As heparin binding and antimicrobial activity of peptides frequently overlap, we here set out to explore possible antibacterial effects of intact a...

Antithrombin III Inhibits Mesangial Cell

Thrombin stimulates and heparin and heparan sulfate inhibit mesangial cell proliferation. In addition, heparin has been shown to inhibit thrombin-stimulated smooth muscle cell proliferation. The anticoagulant action of heparin is mediated by antithrombin Ill. This study investigated whether heparin’s antiproliferative action is also mediated by antithrombin Ill. To this end, the effect of antit...

Isolated oligohydramnios is not an indicator for adverse perinatal outcome.

OBJECTIVES To assess the impact of isolated oligohydramnios on Perinatal outcomes. METHODS A prospective Cohort Study was conducted at the department of Obstetrics and Gynaecology, The Aga Khan University Hospital, Karachi, Pakistan. Pregnant women with isolated oligohydramnios were recruited for the study after obtaining informed consent. The mode of delivery and perinatal outcome were compa...

Molecular weight analysis of antithrombin III-heparin and antithrombin III-thrombin-heparin complexes.

The molecular interactions between components of the heparin-catalyzed antithrombin III/thrombin reaction were investigated by light scattering. When heparin was added to antithrombin III, the molecular weight increased to a maximum and then decreased to that of a 1:1 (antithrombin III X heparin) complex. The initial molecular weights at low heparin to antithrombin III ratios were consistent wi...